Age-Related Changes in Cerebral Blood Flow Values Measured Using Arterial Spin Labeling in Different Brain Regions of the Elderly

Motivation: In clinical work, there is an urgent need to understand the changes in CBF in different brain regions of normal elderly people to detect abnormalities. Goal(s): to investigate and understand age-related changes in CBF values measured using ASL in different brain regions of the elderlyApproach: we recruited 344 healthy elderly participants and employed ASL magnetic resonance imaging to measure CBF values in multiple brain regions. We segmented the brain into distinct ROIs and quantified CBF values for each ROI. Results: CBF reduction was manifested in some areas.Overall brain CBF decreases in both sexes begin at age 60 yearsImpact: provides valuable insights into age-related alterations in CBF values measured using ASL in different brain regions of the elderly. Understanding these changes is crucial for developing strategies to support healthy brain aging and prevent cognitive decline in older populations