Quantification of 1H-MRSI metabolites in mild traumatic brain injury using relaxation correction from MRF
Motivation: Accurate 1H-MRS metabolite quantification requires adjustments for metabolite and water signal relaxation, which are challenging to measure. Goal(s): Our goal was to examine whether an MRF-based correction of subject-specific water relaxation times, applied to patients with mild traumatic brain injury (mTBI), yields results and effect sizes comparable with a conventional literature-based correction approach that utilizes one set of relaxation times for all subjects. Approach: MRF and 1H-MRSI were acquired in 21 mTBI patients and 20 age-matched controls for quantification of metabolite concentrations in six white matter regions. Results: Both methods yielded similar findings with comparable effect sizes across all metabolites in all regions. Impact: In the context of intermediate TR and short TE, the standard absolute quantification method based on one literature-derived set of water relaxation times for all subjects may be appropriate for studying white matter metabolism in mild traumatic brain injury.
Authors
- Guillaume Madelin (ORCID: https://orcid.org/0000-0002-5556-5792)
- Stephen P. Wall (ORCID: https://orcid.org/0000-0003-3965-5074)
- Seena Dehkharghani (ORCID: https://orcid.org/0000-0002-3141-1094)
- Mickaël Tordjman (ORCID: https://orcid.org/0000-0001-8212-7790)
- Sinyeob Ahn (ORCID: https://orcid.org/0000-0002-4188-8304)
- Jonathan Silver (ORCID: https://orcid.org/0000-0002-1841-424X)
- Teresa Gerhalter (ORCID: https://orcid.org/0000-0001-9734-4632)
- Tamara Bushnik (ORCID: https://orcid.org/0000-0003-3328-257X)
- Rosemary Peralta
- Martin Gajdošík (ORCID: https://orcid.org/0000-0003-1570-2825)
- Ivan I. Kirov (ORCID: https://orcid.org/0000-0001-5641-8578)
- Brian Im (ORCID: https://orcid.org/0000-0001-5902-0610)
- Sulaiman Sheriff (ORCID: https://orcid.org/0009-0007-2491-2273)
- Anna Chen
- Mia Gajdošík
- Alejandro Zarate
- Andrea Klein
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3666
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00