Evaluation the value of Gd-EOB-DTPA-Enhanced MRI -derived FLIS and spontaneous portosystemic shunt (SPSS) for liver function reserve

Motivation: To evaluate the diagnostic value of functional liver imaging score (FLIS) and spontaneous portosystemic shunt (SPSS) in patients with chronic liver disease. Goal(s): We expect FLIS and SPSS to have a good correlation with Child-Pugh (CP) class in patients with chronic liver disease. Approach: Analyzed the correlation between MRI parameters and CP class. ROC curves of different indexes were calculated to distinguish CP class. Results: FLIS and three FLIS parameters showed strong to very strong correlation with CP class. The AUC of FLIS is higher than other metrics. The correlation between SPSS and the CP class of CLD patients is not significant. Impact: The presence of SPSS can serve as an imaging biomarker for further stage of cirrhosis, and can indicate cirrhosis patients with SPSS need closer monitoring. We will keep following up the relationship between SPSS and occurrence of malignant liver events.