Diagnosing LGE-negative hypertrophic cardiomyopathy with T1 mapping and feature tracking: a preliminary study

Motivation: The presence of myocardial fibrosis in HCM has significant prognostic power in the prediction of severe cardiac complications in HCM. Goal(s): To compare native T1、ECV and myocardial strain parameters in patients with LGE-negative HCM with healthy participants to evaluate for the presence of subtle myocardial fibrosis and regional myocardial function in HCM. Approach: Seventeen patients with LGE-negative HCM and twenty-eight healthy participants were underwent the MRI scan and the quantitative parameters were analyzed. Results: Overall native T1 and ECV values were increased in HCM patients ; GLS, GRS, and GCS were all decreased in HCM patients with LGE negative. Impact: The cardiac magnetic resonance T1 mapping technique combined with the feature tracking technique can reflect subtle myocardial fibrosis, myocardial deformation, and impaired myocardial systolic function earlier in HCM patients from LGE negative patients.