Investigating the relationship between multi-scale perfusion and myelin content in MS

Motivation: This study investigates the complex pathology of multiple sclerosis (MS), focusing on the relationship between cerebral perfusion and myelin integrity. Goal(s): Utilizing selective inversion recovery (SIR) to determine myelin content through the macromolecular (PSR), and a combined spin- and gradient-echo (SAGE) sequence to assess micro- and macrovascular perfusion,Approach: This study aims to uncover the interplay of hemodynamic impairments and myelin repair in MS. Results: In a cohort of individuals with RRMS and healthy controls, we found significant correlations between PSR and microvascular perfusion within lesions, suggesting a possible link between myelin integrity and cerebral blood flow. Impact: Uncovering specific pathological changes in MS lesions may enhance diagnostic accuracy and disease monitoring. Such insights could also drive the creation of new therapies focused on remyelination and neuroprotection, potentially altering the treatment landscape for MS.