Accelerating high-resolution microstructure mapping based on multi-shell diffusion MRI for acute ischemic stroke

Motivation: The long scanning time of multi-shell diffusion MRI precludes many promising microstructural models to be applied in acute diseases. Goal(s): To achieve high-resolution microstructural mapping in acute ischemic stroke. Approach: We fine-tuned the previously proposed DeepHIBRID method with a multi-shell protocol of 5-minute constraint. Results: 14 maps from 4 diffusion models were obtained, with whole brain coverage and 1.3mm isotropic voxel size. Preliminary results showed decent contrasts to reveal lesions, and the microstructural information indicated was in agreement with the expected pathologies for both chronic and acute cases. Impact: High-resolution microstructural mapping based on multi-shell diffusion MRI should be now feasible for acute diseases, which is rarely possible either with compromised spatial resolution or brain coverage.