High Lp(a) (Lipoprotein[a]) Is Associated with Wall Enhancement and Irregular Pulsation of Unruptured Intracranial Aneurysm

Motivation: Atherosclerotic proteins have been implicated with inflammation and remodeling of aneurysm wall. Both aneurysm wall enhancement (AWE) and irregular pulsation have been suggested as potential candidates for intracranial aneurysms (IAs) instability. Goal(s): To explore the association between atherosclerotic proteins and AWE and irregular pulsation. Approach: Using vessel wall MRI and four-dimensional computed tomography angiographyResults: We found higher level of serum Lp(a) (Lipoprotein[a]) was significantly associated with increased wall enhancement and irregular pulsation of IAs (both p<0.05)Impact: This study established a link between atherosclerotic proteins and AWE and irregular pulsation, inflammation and wall remodeling.