A novel ADAMTS-specific MR peptide probe for characterization of atherosclerotic plaques in a murine model
Motivation: A precise diagnosis of atherosclerosis is of clinical importance, since cardiovascular disease remain one of the leading causes of death worldwide. Goal(s): The goal of this study was to evaluate the feasibility of characterizing a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS4) using molecular magnetic resonance imaging in a preclnical model of atherosclerosis. Approach: Molecular magnetic resonance imaging using a novel probe targeted against ADAMTS4 was used in a high-fat murine model. Results: It was possible to image atherosclerotic lesions in a mouse model using an ADAMTS4- specific probe for magnetic resonance imaging. Impact: Using molecular MRI targeting ADAMTS4 is a promising method for characterization of plaque composition and could possibly impact plaque vulnerability assessment in the diagnosis and treatment of atherosclerosis in patients.
Authors
- Lisa C. Adams (ORCID: https://orcid.org/0000-0001-5836-4542)
- Bernd Hamm (ORCID: https://orcid.org/0000-0002-9141-027X)
- Julia Brangsch (ORCID: https://orcid.org/0000-0002-5533-8004)
- Wolfram C. Poller (ORCID: https://orcid.org/0000-0002-4632-5551)
- Michael Weller (ORCID: https://orcid.org/0000-0002-1748-174X)
- Dilyana B. Mangarova (ORCID: https://orcid.org/0000-0001-5954-3710)
- Matthias Taupitz (ORCID: https://orcid.org/0000-0002-2994-8263)
- Carolin Reimann (ORCID: https://orcid.org/0000-0002-1742-3371)
- Christine Verlemann (ORCID: https://orcid.org/0000-0002-6127-7519)
- Marcus R. Makowski (ORCID: https://orcid.org/0000-0001-8778-647X)
- Uwe Kärst (ORCID: https://orcid.org/0000-0002-1774-6787)
- Jan O. Kaufmann
- Avan Kader (ORCID: https://orcid.org/0000-0002-5453-1267)
- Jennifer L Heyl (ORCID: https://orcid.org/0009-0002-7613-5115)
- Peter Niehaus
- Antje Ludwig (ORCID: https://orcid.org/0000-0002-8369-7020)
- Jana Moeckel
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3961
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 0.00