First Evidence of sustained reduction of Essential Tremor with MR-Guided Low-Energy Ultrasound Neuromodulation
Motivation: Transcranial Ultrasound Stimulation (TUS) is a non-invasive technology for brain stimulation, particularly suited for the neuromodulation of deep brain structures. Goal(s): We investigated the behavioral effects of low-energy TUS in the thalamus in Essential Tremor patients scheduled for MR-guided ultrasound treatment. Approach: Two targets were tested: the ventral intermediate nucleus of the thalamus (VIM) and the dentato-rubro-thalamic tract (DRT). MRI was used for procedure guidance and monitoring. The effect was recorded using MR-compatible accelerometers. Results: VIM low-energy neuromodulation induced transient change in tremor power (p-value< 0.001). DRT neuromodulation reduced tremor power (p-value<0.001) with a sustained post-effect, without MR-thermometry exhibiting any significant thermal rise. Impact: High precision focusing enhanced by state of the art transcranial aberration correction allowed unprecedent transient tremor reduction in Essential Tremor patients following low-energy thalamic ultrasound stimulation under MRI guidance.
Authors
- Cécile Galléa (ORCID: https://orcid.org/0000-0001-8070-8794)
- Marie Vidailhet (ORCID: https://orcid.org/0000-0002-2409-9143)
- Nadya Pyatigorskaya (ORCID: https://orcid.org/0000-0002-2070-1299)
- Yeruham Shapira (ORCID: https://orcid.org/0000-0002-3715-2695)
- Stéphane Lehéricy (ORCID: https://orcid.org/0000-0002-5802-3518)
- Éric Bardinet (ORCID: https://orcid.org/0000-0001-8652-8751)
- Mathieu Santin (ORCID: https://orcid.org/0000-0003-4251-0538)
- Carine Karachi (ORCID: https://orcid.org/0000-0002-4011-6564)
- Élodie Hainque (ORCID: https://orcid.org/0000-0001-9049-6246)
- Jean‐François Aubry (ORCID: https://orcid.org/0000-0003-2644-3945)
- Benoît Béranger (ORCID: https://orcid.org/0000-0003-0704-9854)
- David Grabli (ORCID: https://orcid.org/0000-0001-6798-4567)
- David Attali (ORCID: https://orcid.org/0000-0002-8295-3889)
- Itay Rachmilevitch (ORCID: https://orcid.org/0000-0003-4290-502X)
- Thomas Bancel (ORCID: https://orcid.org/0000-0002-7612-7273)
- Alexandre Dizeux (ORCID: https://orcid.org/0000-0002-7394-143X)
- Mélanie Didier
- Sara Fernandez Vidal
- Maxime Daniel
- Mickaël Tanter (ORCID: https://orcid.org/0000-0001-7739-8051)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/1283
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00