Quantitative and qualitative parameters of DCE-MRI predict CDKN2A/B homozygous deletion in gliomas

Motivation: Homozygous deletion (HD) of cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) holds important prognostic value in gliomas. Goal(s): This study aims to explore the predictive potential of conventional MRI imaging parameters combined with dynamic contrast-enhanced (DCE) MRI parameters in predicting CDKN2A/B HD status in gliomas. Approach: Conventional MRI features and DCE-MRI qualitative parameter time-intensity curve types, quantitative parameters Ktrans, Kep, Ve, Vp, and iAUC were obtained. Logistic regression models for prediction of CDKN2A/B HD status were constructed. Results: Ktrans can serve as valuable predictive parameters for identifying CDKN2A/B HD status in all glioma patients as well as patients with IDH-mutant or IDH-wild gliomas. Impact: Our findings provide a foundation for precise preoperative non-invasive diagnosis and personalized treatment approaches for glioma patients.