High-Resolution 3D Magnetization-Prepared GRE with Inherent Phase-cycling (iPC MP-GRE)

Motivation: Magnetization-prepared (MP) 3D gradient-echo (GRE) MRI sequences suffer from T1 relaxation-induced artifacts, necessitating short echo train lengths. Paired phase-cycling (pPC) mitigates this but at the cost of doubled scan time. Goal(s): This research introduces inherent phase-cycling (iPC) to 3D MP-GRE sequences, aiming to eliminate T1-related artifacts without extending scan time.Approach: iPC combines random PC+ and PC- acquisitions within a single 3D sequence. It is demonstrated that iPC, coupled with compressed sensing reconstruction, achieves high-resolution imaging without scan time increase.Results: iPC significantly reduces ghosting and blurring artifacts compared to pPC, with potential applications in accelerated and artifact-free MRI.Impact: The iPC MP-GRE sequence improves image quality while reducing scan time and complexity. It promises faster, clearer diagnostic imaging, benefiting medical research and patient care, and opens doors to broader applications in quantitative parameter mapping and beyond.