MR Elastography as a Potential Imaging Biomarker and Non-Invasive Method for Diagnosing Spontaneous Intracranial Hypotension
Motivation: Spontaneous intracranial hypotension (SIH) is a debilitating disease with a normal brain MRI in 20% of cases. Goal(s): Our goal was to use MR elastography (MRE) to identify unique viscoelastic patterns in SIH patients. Approach: We performed brain MRE in 15 SIH patients and compared their mechanical properties to 65 healthy controls. Results: SIH patients exhibited significant differences in both stiffness and damping ratio compared to healthy controls. Impact: We demonstrate MRE as a potential imaging biomarker and a non-invasive method for diagnosing SIH, including patients with a normal brain MRI.
Authors
- Ian T. Mark (ORCID: https://orcid.org/0000-0002-4036-2992)
- Matthew C. Murphy
- Ajay A. Madhavan (ORCID: https://orcid.org/0000-0003-1794-4502)
- John Huston (ORCID: https://orcid.org/0000-0003-0584-9460)
- Jeremy K. Cutsforth‐Gregory (ORCID: https://orcid.org/0000-0002-5689-4424)
- Petrice Cogswell
- Waleed Brinjikji (ORCID: https://orcid.org/0000-0001-5271-5524)
- Pragalv Karki (ORCID: https://orcid.org/0000-0002-4234-6945)
- Steven Anthony Messina (ORCID: https://orcid.org/0000-0002-0861-8628)
- John Jing-Wei Chen (ORCID: https://orcid.org/0000-0003-3644-7528)
- Richard L. Ehman (ORCID: https://orcid.org/0000-0001-7041-5074)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4924
- Primary Topic
- Neurosurgical Procedures and Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00