Quantitative MRI to evaluate the efficacy of immunotargeted therapy in unresectable hepatocellular carcinoma

Motivation: Quantitative MRI maybe helpful for evaluating the immunotargeted therapy efficacy in unresectable HCC. Goal(s): To investigate the feasibility of quantitative MRI parameters for evaluating the immunotargeted therapy efficacy in unresectable HCCApproach: Statistics analysis was used to study the alterations in patients with unresectable HCC at baseline and 2 months, 4 monthsafter immunotherapyResults: The ADC value of HCC increased,the longest diameter of HCC initially increased and then decreased. The ADC value and ΔT1% of HCC target lesions in partial response group increased significantly. In progressive disease group, the ΔT1% of HCC target lesions decreased significantly, and ADC values showed a downward trend. Impact: This is the first report to evaluate the immunotargeted therapy in unresectable HCC using quantitative MRI techniques.