Glymphatic activity changes in patients with chronic insomnia：a DTI-ALPS study

Motivation: Long-term chronic insomnia is considered to be a high risk factor for dementia,but the relationship between insomnia and glymphatic activity is unclear. Goal(s): Aim to explore the relationship between the changes of DTI-ALPS index and mental and psychological performance in chronic insomnia patients. Approach: 20 patients diagnosed with chronic insomnia (CR) and 20 control subjects (HC) , MRI scanning, and DTI-ALPS analysis. Results: The glymphatic function activity of individuals with chronic insomnia is lower compared to the normal control group, and age independently influences this. There were significant correlation between the DTI-ALPS index, the scores of PSQI and MMSE. Impact: Chronic insomnia can cause a decrease in brain glymphatic function, and age is an independent factor that affects glymphatic function. Additionally, sleep quality and neuropsychological performance are also related to changes in glymphatic function.