Myocardial tissue characterization by CMR for the evaluation of heart failure with preserved ejection fraction in hypertrophic cardiomyopathy.

Motivation: The association between myocardial tissue characteristics detected by cardiac magnetic resonance (CMR) and heart failure with preserved ejection fraction (HFpEF) in hypertrophic cardiomyopathy (HCM) remains unclear. Goal(s): We sought to evaluate the role of myocardial tissue characteristics detected by CMR in the identification of HFpEF in HCM. Approach: CMR was used to access tissue characteristics including native T1 values, extracellular volume fraction (ECV) and indexed ECV (iECV). Results: Native T1 was a sensitive biomarker independently associated with the diagnosis of HFpEF-HCM. Impact: The inclusion of myocardial tissue characteristics by cardiac magnetic resonance in the diagnostic algorithms of heart failure with preserved ejection fraction in patients with hypertrophic cardiomyopathy should be considered in clinical practice and future studies.