Determining the Reproducibility and Reliability of 2D- and 4D flow MRI Mitral Valve Regurgitation Quantification Methods

Motivation: Mitral valve regurgitation (MVR) quantification is crucial for diagnosis and treatment of patients with mitral valve disease. While different MRI based MVR quantification methods exist, their correlation with one another and their reproducibility and reliability remains unknown. Goal(s): To determine the reproducibility and reliability of four different 2D- and 4D flow MVR volume quantification methods based on CMR. Approach: The intermethod, inter- and intra-reader agreements between four different methods, 4D-flowAIM, 2D-PCstandard, 2D-PCMV, Volumetric, were compared for patients with severe secondary MVR. Results: Among all techniques, 2D-PCstandard and Volumetric methods were the most reliable ones (ICC>0.99, P-value<0.001). Impact: 2D-PCstandard and Volumetric methods quantify the MVR volume most consistently and further research with diverse MVR types and larger cohorts is needed to establish reliable conclusions for 2D-PCMV and 4D-flowAIM methods.