Hyperintense globus pallidus rim sign on 7T MRI is a novel biomarker of neurological Wilson’s disease
Motivation: Excessive subcortical metal deposition seen on susceptibility imaging has suggested a characteristic pattern in neurological Wilson’s disease (NWD). Goal(s): To develop a novel imaging biomarker of NWD using 7T SWI. Approach: WD patients, monoallelic ATP7B variant carriers, health controls, and patients with comparable clinical or imaging manifestations were recruited for development of a novel biomarker of NWD and exploratory comparative analysis. All underwent 7T SWI with quantitative susceptibility mapping and principal component analysis performed. Results: The novel biomarker of NWD termed "hyperintense globus pallidus rim sign" showed high diagnostic accuracy. It revealed a special metal deposition pattern in the lenticular nucleus in NWD. Impact: A novel imaging biomarker of neurological Wilson’s disease (NWD) termed "hyperintense globus pallidus rim sign" could aid the diagnosis and monitoring of NWD.
Authors
- Ting Feng (ORCID: https://orcid.org/0000-0001-5170-8365)
- Huizi Ma (ORCID: https://orcid.org/0000-0002-3845-8020)
- Junhong Zhou (ORCID: https://orcid.org/0000-0002-7931-7646)
- Joyce Ching Mei Lam (ORCID: https://orcid.org/0000-0001-9368-4752)
- Huiqing Zhao (ORCID: https://orcid.org/0000-0002-7875-8896)
- Petr Dušek (ORCID: https://orcid.org/0000-0003-4877-9642)
- Z T Zhang (ORCID: https://orcid.org/0000-0002-3517-5383)
- Sujun Zheng (ORCID: https://orcid.org/0000-0002-6367-5764)
- A. Jon Stoessl (ORCID: https://orcid.org/0000-0002-9778-7246)
- Dongning Su
- Tingyan Yao (ORCID: https://orcid.org/0000-0003-0910-989X)
- Zhan Wang (ORCID: https://orcid.org/0000-0002-1335-4698)
- Ning Wei (ORCID: https://orcid.org/0009-0008-1724-8578)
- Yue Suo (ORCID: https://orcid.org/0000-0002-0632-0262)
- Zhe Zhang (ORCID: https://orcid.org/0000-0001-8220-8443)
- Xiaoping Wang (ORCID: https://orcid.org/0000-0003-1419-3862)
- Li Yuan (ORCID: https://orcid.org/0000-0002-1816-5618)
- Jing Jing (ORCID: https://orcid.org/0000-0001-9822-5758)
- Xinyao Liu (ORCID: https://orcid.org/0009-0007-0478-8981)
- Wanlin Zhu (ORCID: https://orcid.org/0000-0002-0525-657X)
- Yi Dong (ORCID: https://orcid.org/0009-0001-1314-6872)
- Tao Wu (ORCID: https://orcid.org/0009-0007-7864-6695)
- Wei Li (ORCID: https://orcid.org/0009-0001-8671-6362)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0665
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00