Characterization of Age-dependent regional T1 and T2 Relaxometry in Asymptomatic Volunteers Using Magnetic Resonance Fingerprinting

Motivation: MRF is a promising quantitative tool to acquire T1 and T2 values simultaneously. However, its regional variations with advancing age needs to be better eluciated. Goal(s): To determine the age-dependent variations in MRF T1 and T2 relaxation maps, and to characterize the quantitative properies of the brain tissue. Approach: MRF maps were acuiqred in 138 asymptomatic volunteers. Voxel-wise correlation analyses were performed, T1 and T2 values were extracted from various regions to further demonstrate their correlations with age. Results: Both T1 and T2 values in extensive regions increased with age. But T2 drops in bilateral temporal poles, insular cortices, putamen, and corticospinal tract. Impact: MRF was introduced as an in vivo quantitation tool for normative brain imaging. It shows great potential in quantifying differences in brain parenchyma related to age variations and precise tissue segmentation that can be applied in radiomics studies.