Longitudinal Study of the Tissue Sodium Concentration in the Human Liver via Quantitative 23Na MRI at 7T

Motivation: A scarcity in literature values for the tissue sodium concentration (TSC) in the healthy liver complicates the evaluation of the TSC in the diseased liver. Goal(s): This study aimed to establish TSC levels in one healthy liver on multiple days to explore potential concentration variations. Approach: The TSC was assessed using B1 field corrected and respiratory-sorted quantitative 23Na MRI. Results: The TSC values obtained in the healthy liver remained stable over a week and aligned with existing literature values. Impact: The study's finding of a consistent tissue sodium concentration (TSC) over time in one healthy liver is a valuable insight. It indicates that changes in liver TSC might be accurately linked to diseases, which could improve diagnosis of liver diseases.