Longitudinal assessment of brain functional connectivity in depressed patients according to resting-state fMRI

Motivation: Given that suicidal ideation (SI) is closely related to social development, it is important to understand the associations between network function and SI (or the non-suicidal ideation, NS) in patients with depression. Goal(s): We aim to investigate brain function changes in depressed patients with SI and NS between baseline (Time 1, TP1) and follow-up (Time 2, TP2; after one year of therapy). Approach: Paired t-tests, repeated-measure ANCOVA, and network-based statistical analysis were used. Results: We found differences in functional activity after treatment, the results surrounded the DMN region in each group. NBS revealed significantly increased functional interconnections of subnetworks after treatment. Impact: Our findings provide more information about potential neural biomarkers of various depressive disorders.