Subcortical Shape Abnormalities in Maintenance Hemodialysis Patients with Sleep Disorder

Motivation: Hemodialysis (HD) patients can cause alterations in brain structure, and often experience cognitive and sleep disorders (SD). However, the mechanism of SD in HD patients is not fully understood. Goal(s): We aimed to assess the changes in subcortical structures of HD patients with SD and to explore the associations with cognitive. Approach: Volumetric and vertex-wise shape analysis approaches were used to investigate the 14 subcortical structural abnormalities. Results: Hemodialysis patients with sleep disorder exhibited significant surface reduction on the right hippocampus. Impact: Atrophy of subcortical structures was observed in the hemodialysis patients. Right hippocampus atrophy is closely associated with sleep disorder, emphasizing the role of hippocampus as viable predictor.