Hemoglobin A and S affects blood R1 differently: a comparative study in healthy controls and sickle cell disease patients
Motivation: Blood R1 (R1Blood) is associated with hematocrit level (Hct). However, it is unclear whether Hct of normal hemoglobin (HctA) and sickle hemoglobin (HctS) have a similar impact on R1Blood. Goal(s): Evaluate the impact of HctA and HctS on R1Blood in healthy controls and SCD patients. Approach: Multiple linear regression with R1Blood as the dependent variable and Hct of combined hemoglobin A and F (HctAF), HctS, age, and sex as independent variables was performed. Results: R1Blood was associated with HctAF, HctS, age, and sex. Moreover, the association between R1Blood and HctS was significantly different from that between R1Blood and HctAF. Impact: Blood R1 is essential in various MRI applications. Our findings are crucial for developing an accurate blood R1 estimation model in sickle cell disease patients.
Authors
- Melanie E. Fields (ORCID: https://orcid.org/0000-0001-6223-4468)
- Andria L. Ford (ORCID: https://orcid.org/0000-0003-0605-8943)
- Jin‐Moo Lee (ORCID: https://orcid.org/0000-0002-3979-0906)
- Yasheng Chen (ORCID: https://orcid.org/0000-0002-1133-452X)
- Chunwei Ying (ORCID: https://orcid.org/0000-0003-1060-3289)
- Hongyu An (ORCID: https://orcid.org/0000-0001-6459-2269)
- Amy Mirro (ORCID: https://orcid.org/0000-0001-5501-7342)
- J. B. Lewis (ORCID: https://orcid.org/0000-0001-5758-245X)
- Cihat Eldeniz (ORCID: https://orcid.org/0000-0002-4457-0916)
- Jenny Yoo
- Kristin P. Guilliams (ORCID: https://orcid.org/0000-0002-5518-3778)
- Michael M. Binkley (ORCID: https://orcid.org/0000-0002-7701-7615)
- Slim Fellah (ORCID: https://orcid.org/0000-0001-6179-6389)
- Yan Wang (ORCID: https://orcid.org/0000-0002-3750-0311)
- Yan Yan (ORCID: https://orcid.org/0000-0002-5917-1475)
- Lucas Musibay
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4372
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00