Development and validation of a rapid robust 3D-MRF with fast online recon suitable for large-scale neuroscientific and clinical applications
Motivation: A number of promising multiparameter mapping approaches have been developed but are not yet in routine-use in clinical and neuroscientific settings. Goal(s): To create a rapid and robust 3D-MRF acquisition/reconstruction package, suitable for large-scale neuroscientific and clinical applications. Approach: 3D-MRF acquisition is developed for 1-mm whole-brain-mapping in 2.5-minutes, with build-in robustness to motion, and quantification bias from B0&B1 inhomogeneities. Highly-efficient reconstruction package is created for online generation of quantitative maps and synthesized-contrasts within 4 minutes of scan-completion, benchmarked using a consumer-grade GPU. Results: The pipeline has been validated on over 100-scans performed across clinical and neuroscientific settings with plan for open-source distribution soon. Impact: The distribution of such an acquisition/reconstruction package should help facilitate wide-spread deployment of multiparameter mapping.
Authors
- Sophie Schauman (ORCID: https://orcid.org/0000-0002-3744-2553)
- M. Gao (ORCID: https://orcid.org/0009-0006-6002-1542)
- Zhitao Li (ORCID: https://orcid.org/0000-0003-3462-6549)
- Bruno Souza Soares
- Congyu Liao (ORCID: https://orcid.org/0000-0003-2270-276X)
- Maya Yablonski (ORCID: https://orcid.org/0000-0002-4432-5275)
- Jason D. Yeatman (ORCID: https://orcid.org/0000-0002-2686-1293)
- Mark Nishimura (ORCID: https://orcid.org/0000-0003-3976-254X)
- Mahmut Yurt (ORCID: https://orcid.org/0000-0003-3280-4217)
- Adam B. Kerr (ORCID: https://orcid.org/0000-0002-3730-9373)
- Xiaozhi Cao (ORCID: https://orcid.org/0000-0001-5095-648X)
- Kawin Setsompop (ORCID: https://orcid.org/0000-0003-0455-7634)
- Nan Wang (ORCID: https://orcid.org/0000-0002-7616-8083)
- Zihan Zhou (ORCID: https://orcid.org/0000-0002-9034-0951)
- Ali Syed
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/1075
- Citations
- 2
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.81