Optimizing b-value Selection in MRI Diffusion Parameters for Hepatocellular Carcinoma: A Comparative Study of IVIM, DKI, and CTRW Models

Motivation: Streamlining the number of b-values in MRI scans for hepatocellular carcinoma can significantly enhance diagnostic efficiency. Goal(s): To identify the minimal b-value pairs that correspond with comprehensive diffusion model parameters, potentially simplifying future scanning protocols. Approach: Employed MRI diffusion parameters across 11 b-values in 35 patients, comparing IVIM, DKI, and CTRW metrics with sADC values derived from varied b-value combinations. Results: Discovered specific b-value pairs that closely matched the diffusion parameters of comprehensive models, suggesting a possible reduction in required b-values for accurate diagnosis. Impact: This study could substantially refine MRI protocols, improving tumor characterization and grading while ensuring data quality with fewer b-values.