Blood-to-CSF Water Exchange Time Estimation Using a multi-PLD, multi-TE 3D RARE Stack-of-Spirals ASL Sequence
Motivation: To assess the blood-CSF barrier on a Siemens platform using a multi-TE 3D RARE stack-of-spirals ASL sequence. Goal(s): To obtain high-quality fitted blood-to-csf time images. Approach: A 3D RARE pCASL sequence with multiple-TE acquisitions was used to collect ASL images. To cope with the low SNR issue in blood-CSF barrier ASL imaging, a denoising technique of locally adaptive low rank regularization with collaborative data selection was applied to images. Results: The fitted blood-to-csf time images generated from denoised control and label images showed significantly improved image quality. The Bland-Altman Plot shows a good agreement between the test and retest scans using the sequence. Impact: Blood-CSF barrier ASL implemented in the Siemens platform showed good test-retest reliability with the help of advanced denoising. The denoising technique can be used for ASL applications to provide high-quality images.
Authors
- María A. Fernández‐Seara (ORCID: https://orcid.org/0000-0001-8536-6295)
- Léonie Petitclerc (ORCID: https://orcid.org/0000-0001-9127-2201)
- John A. Detre (ORCID: https://orcid.org/0000-0002-8115-6343)
- Matthias J.P. van Osch (ORCID: https://orcid.org/0000-0001-7034-8959)
- Hangfan Liu (ORCID: https://orcid.org/0000-0002-1207-7713)
- Manuel Taso (ORCID: https://orcid.org/0000-0003-2405-9165)
- M. Dylan Tisdall (ORCID: https://orcid.org/0000-0002-0454-3112)
- Marta Vidorreta (ORCID: https://orcid.org/0000-0002-4272-3691)
- Yiran Li (ORCID: https://orcid.org/0000-0001-7922-7766)
- Bo Li (ORCID: https://orcid.org/0000-0003-4885-0656)
- Yulin V. Chang (ORCID: https://orcid.org/0000-0003-2714-2634)
- Ze Wang (ORCID: https://orcid.org/0000-0002-9431-8356)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3261
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00