Magnetic Resonance Elastography to Identify Prostate Phenotypes of Lower Urinary Tract Symptoms
Motivation: There is a critical need for significant improvements in image-based assessment of the prostate in men with lower urinary tract symptoms (LUTS). Goal(s): To develop non-invasive image-based biomarkers that will optimize clinical management of men with LUTS. Approach: Quantify transition zone complex shear modulus (henceforth ‘stiffness’) with transperineal magnetic resonance elastography (pMRE) at 90Hz and 100Hz. Results: Mean periurethral TZ stiffness increases with frequency (3.0clip_image006.png">0.4kPa). Impact: Transperineal pMRE is technically feasible, generates volumetric whole prostate quantitative parametric maps that can differentiate zonal prostate anatomy. Periurethral TZ stiffness, measured with pMRE, may be a clinically useful biomarker for identifying discrete phenotypes of LUTS.
Authors
- Christopher L. Brace (ORCID: https://orcid.org/0000-0002-6777-6554)
- Matthew D. Grimes (ORCID: https://orcid.org/0000-0002-4409-9263)
- William A. Ricke (ORCID: https://orcid.org/0000-0002-9807-2090)
- Timothy J. Hall (ORCID: https://orcid.org/0000-0001-9850-6031)
- Cody Johnson (ORCID: https://orcid.org/0000-0003-3028-406X)
- Juan Pablo Gonzalez‐Pereira (ORCID: https://orcid.org/0000-0002-3580-3570)
- Alejandro Roldán‐Alzate
- Vikas Gulani (ORCID: https://orcid.org/0000-0003-0889-5999)
- Shane A. Wells (ORCID: https://orcid.org/0000-0002-1067-6624)
- Yun Jiang (ORCID: https://orcid.org/0000-0002-0713-9641)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/3512
- Primary Topic
- Infrared Thermography in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00