Renal Metabolic CEST-MRI Based on Golden-Angle Radial Sampling Under Free Breathing

Motivation: Respiration motion may induce artifact in CEST image and the in-accurate quantization of CEST signal. Goal(s): We aimed to develop clinical motion-insensitive CEST imaging of kidney. Approach: Here, we used turbo filed echo (TFE) based on golden-angle radial sampling to readout renal CEST image under free breathing of three normal volunteers and also evaluated its effectiveness for motion artifact suppression. Results: The renal Z-spectrum is float and there is no motion artifact in CEST images. This motion in-sensitive sequence showed high repeatability for renal CEST imaging. Impact: It may provide a motion in-sensitive CEST imaging sequence for renal imaging in clinical nephropathy patients under free breathing, and improve the accuracy of injury detection.