Enabling reproducible measurements of Fat Fraction and Iron content using an SI traceable reference phantom
Motivation: Quantitative MRI is a powerful tool for measuring a variety of biological parameters, with two common biomarkers of interest being fat fraction and Iron content. Goal(s): We present here a test object for these parameters which is supported by fundamental metrology and traceable to the SI system. Approach: Initial scan data taken at 1.5T is compared with traceable measurements of phantom propertiesResults: We see significant variation seen in clinical results of the same phantom even with standardised protocols, outside the range of phantom validation. Impact: We demonstrate a new gold standard and verified phantom for fat and iron measurement, traceable to primary standards. We present results using standardised MRI protocols which is vital for understanding and improving standards and best practice guidelines in the future.
Authors
- Shelley Rhodes (ORCID: https://orcid.org/0000-0001-7195-8759)
- Lejla Gurbeta Pokvić (ORCID: https://orcid.org/0000-0002-4986-6142)
- Amar Deumić
- S.N. Rai
- Tugba Dispinar
- Paul S. Tofts (ORCID: https://orcid.org/0000-0002-8552-2419)
- Alessandra Manzin (ORCID: https://orcid.org/0000-0002-4078-2321)
- Alen Bošnjaković (ORCID: https://orcid.org/0000-0002-2167-8713)
- Adriano Troia (ORCID: https://orcid.org/0000-0002-4199-8220)
- Christian Ward-Deitrich (ORCID: https://orcid.org/0000-0002-5204-2443)
- Amy McDowell
- John A. Thornton (ORCID: https://orcid.org/0000-0001-9976-9714)
- Sarah Hill (ORCID: https://orcid.org/0000-0002-7480-0655)
- Holly Elbert
- Robert D. Hanson
- Matt Hall (ORCID: https://orcid.org/0000-0001-7778-5887)
- Riccardo Ferrero (ORCID: https://orcid.org/0000-0001-9243-2975)
- Matt Cashmore (ORCID: https://orcid.org/0009-0002-6081-9053)
- Cormac McGrath (ORCID: https://orcid.org/0000-0002-8215-3646)
- Stephen Wastling (ORCID: https://orcid.org/0000-0003-4648-9932)
- Jonathon Delve
- Siân Curtis (ORCID: https://orcid.org/0000-0001-5225-860X)
- Nadia Smith (ORCID: https://orcid.org/0000-0002-6503-3001)
- İlker Ün (ORCID: https://orcid.org/0000-0001-5089-4602)
- S. Busoni (ORCID: https://orcid.org/0000-0001-7453-007X)
- Merima Smajlhodžić-Deljo
- Cailean Clarkson
- Frédéric Brochu
- Aaron McCann
- Richard A. Scott
- Jessica Goldring
- Jonathan Clarke
- Nick Zafeiropoulos
- Elizabeth Cooke
- Asante Ntata
- Stanislav Strepokytov
- Ben Tatman
- Cameron Ingham
- Katie Obee
- Asha Ford-Scille
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4838
- Citations
- 1
- Primary Topic
- Body Composition Measurement Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.33