Fractality and Lacunarity of Tumor subcomponents is a Measure of Overall Survival: A novel approach to decipher Tumor Geometry and Survival

Motivation: Gliomas of similar histologic grade show a lot of difference in the growth and development. And the survival of patients with similar histologic grades also vary. Goal(s): The shape variations of gliomas impact survival or not. Approach: We calculated the fractal dimension and lacunarity of the subcomponents of gliomas and analyzed them along with survival data to obtain differences in overall survival. Results: Variations in fractal Dimension and Lacunarity also present variations in overall survival. Subjects with higher enhancing fractal dimension had shortened survival and it was opposite for nonenhancing fractal dimension and enhancing lacunarity. Survival did not depend on edema subcomponent. Impact: The study's results could revolutionize glioma patient care. Clinicians may integrate fractal dimension and lacunarity as prognostic markers for tailored treatment decisions. Scientists may explore their use in combination with genetic factors for accurate survival predictions and improving patient outcomes.