Banding insensitive DESPO for T1 and T2 mapping applied to 3D prostate at 3T.

Motivation: DESPO is a robust T2 brain mapping technique based on balanced steady-state free precession (bSSFP). However, it is susceptible to off-resonance artifacts, especially in areas with high susceptibility changes, such as the prostate. Goal(s): Our proposed method, DESPO+, integrates the complete bSSFP and spoiled-gradient echo (SPGR) models, using a simulation-based approach for 3D T1/T2 maps in the prostate region. Approach: We employed a simulated-based method of the full bSSFP and SPGR models incluiding off-resonance to reconstruct T1/T2/PD simultaneously. Results: DESPO+ provides off-resonance insensitive with high-resolution 3D T1/T2 mapping, synthesizing T1-weighted/T2-weighted images using a short scan time of 3.6 minutes, similar to DESPO. Impact: DESPO+ provides an off-resonance insensitive and customizable solution, enabling high-resolution 3D T1/T2 mapping and synthesized T1-weighted/T2-weighted images for the entire prostate, all achieved within a short scan time of 3.6 minutes, similar to DESPO.m