Resting-state changes along the cortical depth detected during evolution of major depressive disorder

Motivation: The relative contribution of each cortical depth to the network disturbances coupled with depression remains unexplored. Goal(s): We aim to identify changes in connectivity along the cortical thickness during depression recovery. Approach: We use high-resolution, large-coverage EPIK to functionally map the brain of patients before and after treatment and perform cortical-depth specific analysis of network connectivity. Results: Changes in connectivity linked to depression treatment were observed at multiple depths of the cortex in two resting-state networks. Impact: The demonstration that network connectivity does not change homogeneously in a patient population along the cortical depth suggests the importance of adding this variable to the analysis of psychiatric disorders to improve understanding of the mechanisms behind network disturbances.