Mapping the Functional Role of White Matter Tracks by fusing Diffusion and Functional MRI

Motivation: The axonal connections in white matter(WM) are vital for brain function, but there is a knowledge gap of the functional role of WM tracks. Goal(s): To address this, we proposed a method to combine diffusion MRI (dMRI) and functional MRI (fMRI) to map the functional role of WM tracks during tasks. Approach: To each WM track generated with dMRI, we define the dynamic functional connectivity (DFC) that reflects the functional interaction of the GM it connects. General linear model(GLM) is then employed to measure the activation level during task. Results: Meaningful tracks that are associated with various tasks, implicating the activated networks. Impact: Our method paves the road to generate a functional atlas of white matter. It is important for understanding the functional architecture of the brain, the mechanism of brain disorders, such as, Schizophrenia, Epilepsy and Traumatic Brain Injury.