Repeatability of Cervix Restriction Spectrum Imaging Outputs in Healthy Cervix

Motivation: The American College of Radiology advocates the integration of DW-MRI in the assessment and post-treatment monitoring of cervical cancer. Restriction Spectrum Imaging (RSI) is an advanced diffusion model which has the potential to separate active malignancy from post treatment changes. Goal(s): Investigate the repeatability of cervix-specific RSI outputs (C1, C2, C3) in healthy cervix. Approach: Performed ‘test’ and ‘retest’ scans of a multi-shell diffusion sequence on nine subjects. Intraclass correlation coefficients (ICC) were calculated for each C-compartment. Results: C1 showed poor agreement, while C2 and C3 showed high agreement. Impact: Cervix-specific RSI outputs C2 and C3 showed high agreement, making steps towards repeatable DW-MRI associated biomarkers. Ensuring their repeatability is crucial for their practical application in clinical settings.