The Application of FunctIonal Renal MRI to improve assessment of Chronic Kidney Disease (AFiRM) Study
Motivation: The need for better biomarkers to assess progression of Chronic Kidney Disease (CKD). Goal(s): To determine if multiparametric MRI can detect changes in structure and function in CKD. Approach: In the Application of Functional Renal MRI (AFiRM) study, multiparametric MRI is to be collected on 400 CKD participants at baseline and Year 2. The MRI protocol comprises T2- and T1-weighted scans, B0 and B1 mapping, T1, T2 and T2* relaxometry, DWI, MTR, PC-MRI and ASL perfusion. Results: To date, 387 have been scanned, with preliminary MRI analyses on 300 datasets for B0 and B1, T1, T2*, MTR, and Total Kidney Volume (TKV). Impact: Application of the UKRIN-MAPS multiparametric renal MRI protocol to study changes in renal structure and function in CKD progression. This will provide definitive evidence on the question of whether MRI is better at tracking disease progression than conventional biomarkers.
Authors
- Andrew N. Priest (ORCID: https://orcid.org/0000-0002-9771-4290)
- Maarten W. Taal (ORCID: https://orcid.org/0000-0002-9065-212X)
- Charlotte Buchanan (ORCID: https://orcid.org/0000-0003-3010-6079)
- Susan Francis (ORCID: https://orcid.org/0000-0003-0903-7507)
- Mark S. Gilthorpe (ORCID: https://orcid.org/0000-0001-8783-7695)
- Iosif Mendichovszky (ORCID: https://orcid.org/0000-0002-3777-2827)
- Steven Sourbron (ORCID: https://orcid.org/0000-0002-3374-3973)
- Nicholas M. Selby (ORCID: https://orcid.org/0000-0003-0351-8326)
- David L. Thomas (ORCID: https://orcid.org/0000-0003-1491-1641)
- Alexander Daniel
- Philip A. Kalra
- Kevin Teh
- David M. Morris (ORCID: https://orcid.org/0000-0002-9387-1213)
- On behalf of the AFiRM investigators
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0779
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00