Reliability of the compressed sensing MPRAGE for brain volume measurement: a comparison study with standard MPRAGE.

Motivation: T1 Magnetization Prepared Rapid Acquisition Gradient Echo (MPRAGE) with compress sensing (CS) offers high-contrast 3D images in a short time compared with standard MPRAGE. To utilize this in daily practice, comparison with existing method is essential. Goal(s): We investigated agreement of volume data obtained by NeuroQuant and test the possibility of CS-MPRAGE as an alternative method to standard-MPRAGE. Approach: We included 95 patients who underwent both CS-MPRAGE and standard-MPRAGE and compared the volume data. Results: CS-MPRAGE yields comparable volumes to standard-MPRAGE for large brain region like the entire cortex. However, small structure such as hippocampus tends to measure smaller with CS-MPRAGE. Impact: CS-MPRAGE offers high-quality 3D images and reliable volume data in significantly less time than standard-MPRAGE. This eliminates need for patients to remain still for extended periods, overcoming a major obstacle in imaging studies.