Alterations in Static and Dynamic Functional Brain Connectivity in Drug-naïve Patients with Early Parkinson’s Disease

Motivation: Long-term levodopa treatment can markedly change the brain connectivity network in Parkinson's disease(PD) patients. The changes of static and dynamic brain network in early PD remain unknown. Goal(s): To investigate the alterations in static and dynamic whole-brain connectivity in early PD patients who have never received dopaminergic therapy. Approach: A case-control study was performed. The static and dynamic functional connectivity were constructed and analysised. Results: PD patients showed alterations in the SMN, DGN, LBN, and VSN, which may be relevant to both motor and non-motor symptoms. LEiDA results showed that PD group displayed a shorter lifetime and lower probability than the HC group. Impact: The study offers neuroimaging evidence of static and dynamic brain functional connectivity changes in drug-naïve early Parkinson's disease patients. It identifies potential biomarkers for clinical Parkinson’s disease diagnosis and assessment.