On the impact of the free pool T2 on quantitative MT‑derived T1 and Macromolecular Proton Fraction values in the MP2RAGE
Motivation: T1 estimations using the MP2RAGE methodology are biased by Magnetization Transfer (MT) effects. A quantitative MT-based solution was previously proposed in which the inversion efficiency of the preparation pulse (Q) was fixed; we sought to alleviate this strong hypothesis. Goal(s): To better understand the influence of free water T2 (T2,f) on Q in the scope of MP2RAGE-T1 brain mapping. Approach: A better modeling of the MP2RAGE involving a discretized preparation pulse is employed, and tested for fixed and free T2,f values. Results: The T1 bias is highly dependent on the T2,f values, calling for a better and accurate estimation of this parameter. Impact: Quantitative MT-derived T1 estimation in the MP2RAGE methodology remains dependent on the estimated free water T2 values because of its impact on the inversion efficiency pulse.
Authors
- Guillaume Duhamel (ORCID: https://orcid.org/0000-0001-5704-8513)
- Olivier M. Girard (ORCID: https://orcid.org/0000-0002-5296-638X)
- Thomas Troalen (ORCID: https://orcid.org/0000-0002-5764-4689)
- Andreea Hertanu (ORCID: https://orcid.org/0000-0003-2464-7872)
- Jean‐Philippe Ranjeva (ORCID: https://orcid.org/0000-0001-8073-102X)
- Lucas Soustelle (ORCID: https://orcid.org/0000-0002-4688-3262)
- Maxime Guye (ORCID: https://orcid.org/0000-0002-4435-2257)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2170
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00