The effect of long label duration on hybrid multi-delay PCASL of time-encoded and variable-TR schemes in Moyamoya disease

Motivation: Accurate quantification of cerebral perfusion in Moyamoya disease using ASL is challenging. Goal(s): To investigate the effect of long LD in hybrid multi-delay PCASL of time-encoded and variable TR schemes. Approach: Patients with Moyamoya disease were scanned with hybrid schemes with respectively 12 delays obtained with LD of 2s (LD2s) and 9 delays obtained with LD of 3s (LD3s). Results: The tSNR of LD3s was significantly higher than that of LD2s, especially in the regions with prolonged ATT. CBF measured by both methods showed a strong correlation, but the differences in CBF became larger for longer ATT. Impact: The use of a long LD of 3s for hybrid multi-delay PCASL provides higher SNR compared to that of 2s, and may be useful for assessing cerebral perfusion with prolonged ATT as often seen in Moyamoya disease.

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Publication Details

Journal
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Published
2024-11-26
DOI
https://doi.org/10.58530/2024/2327
Primary Topic
Cerebrovascular and genetic disorders
Type
article
Field-Weighted Citation Impact
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article

The effect of long label duration on hybrid multi-delay PCASL of time-encoded and variable-TR schemes in Moyamoya disease

Ryoji Mikayama, Marc Van Cauteren, Shota Ishida, Makoto Obara et al.
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Cerebrovascular and genetic disorders
article

The effect of long label duration on hybrid multi-delay PCASL of time-encoded and variable-TR schemes in Moyamoya disease

Ryoji Mikayama, Marc Van Cauteren, Shota Ishida, Makoto Obara, Osamu Togao, Tatsuhiro Wada, Kim van de Ven, Chiaki Tokunaga, Koji Yamashita, Matthias J.P. van Osch, Kousei Ishigami, Kazufumi Kikuchi, Lena Václavů
article en

Abstract

Motivation: Accurate quantification of cerebral perfusion in Moyamoya disease using ASL is challenging. Goal(s): To investigate the effect of long LD in hybrid multi-delay PCASL of time-encoded and variable TR schemes. Approach: Patients with Moyamoya disease were scanned with hybrid schemes with respectively 12 delays obtained with LD of 2s (LD2s) and 9 delays obtained with LD of 3s (LD3s). Results: The tSNR of LD3s was significantly higher than that of LD2s, especially in the regions with prolonged ATT. CBF measured by both methods showed a strong correlation, but the differences in CBF became larger for longer ATT. Impact: The use of a long LD of 3s for hybrid multi-delay PCASL provides higher SNR compared to that of 2s, and may be useful for assessing cerebral perfusion with prolonged ATT as often seen in Moyamoya disease.

Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Openalex Percentile: Top 67%
Cerebrovascular and genetic disorders
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