Structural Volumetric and Periodic Table DTI Patterns in Complex Normal Pressure Hydrocephalus – Towards Principles of a Translational Taxonomy

Motivation: The Periodic Table of DTI Elements organizes neural tract patterns by their diffusivity and neural properties but mainly describes white matter injury. Goal(s): Our goal was to expand the utility of this methodology by interrogating other subcortical and cortical structures of interest and comparing them to brain metrics in controls derived from an open-access dataset. Approach: We examined brain volumes and DTI profiles in Complex Normal Pressure Hydrocephalus (CoNPH) vs. healthy controls from ADNI. Results: Lateral ventricular volumes were significantly higher but most other volumes significantly lower in CoNPH vs. controls. Most DTI metrics (supratentorial and infratentorial) were significantly higher in CoNPH. Impact: The Periodic Table of DTI Elements can demonstrate white matter and cortical injury and alterations of grey matter structures. The strategy can be used to compare cohorts with controls-in-common from an open-access dataset for wider community use.