A comprehensive MRI-based human craniofacial atlas

Motivation: Current research lacks an understanding of the relationship between the craniofacial structure and the brain, and this connection is of significant importance for pre-diagnosis and neuroscience research. Goal(s): Develop a MRI-based craniofacial atlas to support clinical-neuroscience research, particularly in understanding the relationship between the brain and craniofacial structure. Approach: Gathered and processed MRI scans from 148 subjects, employing specialized algorithms for detailed craniofacial and skull mapping, aiding neuroscience research. Results: The study revealed variations in skull thickness, particularly in the occipital bones, and a significant negative correlation between cortical and skull thickness in specific regions. A comprehensive facial atlas was also successfully developed. Impact: Our research provides a clear research framework and atlas that can be used to explore the relationship between neurological disorders and craniofacial morphological changes in future studies. Additionally, it offers a potential approach for non-invasive and rapid preclinical diagnosis.