Topological network analysis and virtual brain modelling combined to portray subject-specific profiles of dementia stages.
Motivation: The high level of heterogeneity typical of mild cognitive impairment (MCI) condition currently hinders the selection of a personalized effective therapy. Goal(s): Our goal is to obtain a personalized profile exploring not only structural and functional topology but also diving in subject-specific physiological parameters. Approach: Starting from structural and functional connectomes, we combined graph theoretical analysis with virtual brain models in the default mode network of healthy subjects, MCI and Alzheimer's disease patients. Results: Our results offer a detailed description of alterations at single-subject level, illustrating differences between dementia stages based on topology and subject-specific physiological parameters. Impact: The personalized profile obtained combining graph theory and virtual brain models portray dementia stages at single-subject level, capturing the wide heterogeneity of mild cognitive impairment and opening new perspectives for personalized effective interventions.
Authors
- Laura Mazzocchi (ORCID: https://orcid.org/0000-0001-7981-1188)
- Anna Pichiecchio (ORCID: https://orcid.org/0000-0002-5654-4088)
- Lisa Maria Farina (ORCID: https://orcid.org/0000-0002-4993-0415)
- Fulvia Palesi (ORCID: https://orcid.org/0000-0001-5027-8770)
- Alfredo Costa (ORCID: https://orcid.org/0000-0001-7312-8011)
- Stefano Francesco Cappa (ORCID: https://orcid.org/0000-0003-1003-3925)
- Francesca Conca (ORCID: https://orcid.org/0000-0003-1809-6541)
- Claudia A. M. Gandini Wheeler‐Kingshott (ORCID: https://orcid.org/0000-0002-4832-1300)
- Marta Gaviraghi (ORCID: https://orcid.org/0000-0001-7427-845X)
- Egidio D’Angelo (ORCID: https://orcid.org/0000-0002-6007-7187)
- Matteo Cotta Ramusino (ORCID: https://orcid.org/0000-0003-3090-9648)
- Roberta Lorenzi (ORCID: https://orcid.org/0000-0003-2034-118X)
- Anita Monteverdi (ORCID: https://orcid.org/0000-0003-0071-9325)
- Marialaura De Grazia
- Eleonora Lupi
- Sofia Manzon
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0961
- Primary Topic
- Cell Image Analysis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00