Pushing MP2RAGE boundaries: ultimate time-efficient parameterization combined with exhaustive T1 synthetic contrasts.

Motivation: Redefining MP2RAGE sequence for clinical efficiency. Goal(s): To provide a time-efficient MP2RAGE parameterization with on-demand synthetic T1-weighted contrasts. Approach: Sequence parameters are chosen to minimize idle time while maximizing CNRWM/GM. Synthetic contrasts are derived from T1 map. Experimental validation is carried for 7T brain imaging using plug-and-play parallel transmission. Results: Time-efficient MP2RAGE reduced acquisition time by up to 40% compared to reference, while maintaining contrast quality. Multiple sclerosis patients benefited from enhanced lesion visualization with a 10min, (0.67mm)3 time-efficient protocol. This optimization enabled shorter acquisition times or higher resolution within a given time budget, while providing an exhaustive set of brain T1-w contrasts. Impact: A time-efficient MP2RAGE sequence parameterization is proposed, resulting in faster, higher-resolution 3D T1-weighted brain imaging compared to conventional settings, combined with a complete set of synthetic T1-w contrasts generated online, with meaningful potential in clinical and research practice.