Perfusion parameters of DCE-MRI using GRASP correlates with tumour cellularity of lung cancer.

Motivation: Tumour cellularity indicates tumour proliferation. Although perfusion MRI parameters have been proposed for non-invasive assessment of tumour cellularity, few studies have validated this theory, particularly in lung cancer. Previous studies provided a free-breathing perfusion MRI method using GRASP. Goal(s): Therefore, our aim is to investigate the relationship between tumour cellularity and perfusion parameters of MRI using GRASP. Approach: Pearson correlation coefficients were used to illustrate the relationship between perfusion parameters and cell density. Results: The findings indicated an inverse correlation between tumour cellularity and Ve. However, the study found no significant correlation between Ktrans and cell density. Impact: It suggests that GRASP perfusion MRI has potential as a non-invasive technique to assess tumour cellularity in lung cancer.