3D whole brain mapping of creatine kinase metabolic rate using 31P-MR fingerprinting.

Motivation: Using 31P MRS combined with magnetization transfer (MT) experiments including saturation transfer or inversion transfer to assess chemical exchange rate of creatine kinase (kCK) in the human brain are time-consuming and limited to 1D-acquisitions. Goal(s): Acquiring a 3D whole brain kCK map. Approach: In this abstract, we introduce an advanced, fast 3D-31P-MRF sequence for the human brain at 7T. Results: The novel 3D-31P-MRF approach is feasible for whole brain mapping of kCK, enabling the investigation of region-specific energy metabolism under various pathological conditions. Impact: Using the novel 3D-31P-MR Fingerprinting approach for whole brain mapping of kCK enables us to investigate region-specific energy metabolism under various pathological conditions and may enhance our understanding of the underlying molecular and metabolic processes.