Neurochemical Correlates of PTSD Severity: Insights from ACC and Hippocampal Metabolite Analysis

Motivation: Neurochemical alterations in PTSD are well-researched across various brain regions, yet understanding their connection to symptoms remains unexplored. Goal(s): Our aim was to determine the association between the neurochemical profile and emotional/cognitive symptoms in diagnosed PTSD individuals and healthy controls. Approach: Participants underwent an MRS scan and CNS Vital Signs survey. Correlations between metabolites and survey scores were examined. Results: We found significant differences across several PTSD symptoms, for which the severity correlated with metabolite levels alterations in the ACC and hippocampus. Impact: By understanding correlation between neurochemical alternations and clinical symptom severity, this study provides valuable insights into the pathways of PTSD. It paves the way for innovative approaches in managing neurological disorders.