Vendor-Neutral Development and Cross-Center Validation of Flip Angle Modulated 2D Sequential CSE-MRI Technique for Liver Fat Quantification
Motivation: 2D sequential chemical-shift-encoded acquisitions with centric encoding and flip-angle modulation (FAM) enables motion-robust and high-SNR liver fat quantification. Originally developed in a single vendor, the performance and relative simplicity of FAM motivate vendor-neutral implementation and validation. Goal(s): Implement FAM in the vendor-neutral framework Pulseq, and determine its feasibility, bias, and reproducibility in a multi-center, multi-vendor study. Approach: Pulseq-FAM was applied in two centers with two vendors on a phantom with controlled PDFF/T1water values, and in volunteers during free breathing. Results: At both centers, Pulseq-FAM shows low bias and good reproducibility in the phantom, and excellent motion robustness and image quality in volunteers. Impact: A vendor-neutral implementation of motion-robust liver fat quantification, as demonstrated in this study, may enable detection, staging, and treatment monitoring of steatotic liver disease with improved availability and standardization.
Authors
- Jon‐Fredrik Nielsen (ORCID: https://orcid.org/0000-0002-2058-3579)
- Jeff Kammerman (ORCID: https://orcid.org/0000-0003-4780-9360)
- Jitka Starekova (ORCID: https://orcid.org/0000-0002-4285-3090)
- Diego Hernando (ORCID: https://orcid.org/0000-0002-0016-0317)
- Jean H. Brittain (ORCID: https://orcid.org/0000-0002-1314-8114)
- Jiayi Tang (ORCID: https://orcid.org/0009-0007-7590-875X)
- Maxim Zaitsev (ORCID: https://orcid.org/0000-0001-7530-1228)
- Shohei Fujita (ORCID: https://orcid.org/0000-0003-4276-6226)
- Scott B. Reeder (ORCID: https://orcid.org/0000-0003-4728-8171)
- Daiki Tamada (ORCID: https://orcid.org/0000-0003-3615-459X)
- Berkin Bilgic̦ (ORCID: https://orcid.org/0000-0002-9080-7865)
- Alan B. McMillan (ORCID: https://orcid.org/0000-0003-4502-6522)
- Yuting Chen (ORCID: https://orcid.org/0009-0003-6232-1141)
- Xingwang Yong
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0955
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.39