Preliminary assessment of 3D-APTWI combined with DWI in differentiating benign and malignant bone and soft tissue tumors

Motivation: Clinical applications of APTWI for differentiating benign and malignant bone and soft tissue tumors are scarce. Goal(s): This work investigated and evaluated the ability of APT and DWI parameters in distinguishing benign from malignant bone and soft tissue tumors. Approach: MTRasym and ADC values of ninety-six patients in benign and malignant lesions were compared using either the independent samples t-test or Mann-Whitney U test. The ROC curve was used to assess the diagnostic performance in differentiation between benign and malignant tumors. Results: APTWI combined with DWI showed a significantly improved differentiation between benign and malignant tumors. Impact: The combination of APTWI and DWI offers valuable insights into changes in cellular proteins and peptides. When MTRasymmax is combined with ADCmin, it yields superior diagnostic performance for distinguishing between malignant and benign bone and soft tissue tumors.