White matter-engaged multilayer network for evaluation of functional deficits in Alzheimer’s disease

Motivation: The role of white matter (WM) in the functional connectivity within brain networks has not been well studied. Goal(s): Our goal was to use a high-order graph model to comprehensively analyze brain functional networks that engage WM. Approach: We constructed multilayer networks and analyzed network parameters in the brains of subjects with Alzheimer’s disease (AD). Results: Multilayer network analysis showed increased sensitivity for detecting significant deterioration in functional connectivity (FC) in AD. Impact: Multilayer networks allow more comprehensive understanding of structure-function relations within the whole brain and may provide deeper insight into the pathophysiology of degenerative brain disease.