Working Memory Prognostication After Concussion Using Glymphatic Biomarkers

Motivation: Addressing persistent working-memory decline (PWMD) in concussion patients is crucial, but prognostic methods are limited. This study explores the potential of the glymphatic system as a novel biomarker. Goal(s): Determine if early measurement of glymphatic dysfunction within 1 month post-concussion can predict PWMD. Approach: A 1-year prospective observational study was conducted, assessing glymphatic function, microhemorrhage, sleep quality, and neurocognitive tests within 1-month of injury. Results: Significant correlations were found between 1-year digit span scores and glymphatic diffusivity and sleep quality. Lower glymphatic function and poor sleep quality correlated with unfavorable long-term working memory outcomes. The 1-year digit span score could be reliably predicted. Impact: This research highlights the importance of monitoring sleep quality and glymphatic function, offering potential therapeutic targets to prevent persistent working-memory decline in concussion patients.