7 Tesla MRI in routine surgical planning for Deep Brain Stimulation for Parkinson’s Disease
Motivation: Identifying the dorsolateral subthalamic nucleus (STN) for deep brain stimulation (DBS) in Parkinson’s disease (PD) can be challenging due to the size and double-oblique orientation. Goal(s): To evaluate the influence of 7T T2w-TSE and probabilistic tractography on STN target planning, micro-electrode recordings and motor improvement. Approach: We describe the implementation of 7T T2w-TSE and probabilistic tractography in 182 PD patients undergoing STN DBS at our centre from 2015-2022. Results: Implementation of 7T T2w-TSE for STN DBS enabled a refinement in targeting which can be used as basis for adding probabilistic subthalamic connectivity, in order to enhance clinical outcome of STN DBS. Impact: The extensive evaluation of 360 STNs has not been described previously and shows 7T T2w-TSE and probabilistic tractography can refine STN targeting and surgical efficiency in DBS for PD.
Authors
- Pepijn van den Munckhof (ORCID: https://orcid.org/0000-0001-5044-3705)
- Wietske van der Zwaag (ORCID: https://orcid.org/0000-0003-3223-9721)
- Maarten Bot (ORCID: https://orcid.org/0000-0001-9719-6086)
- Niels Rijks (ORCID: https://orcid.org/0000-0001-9285-094X)
- Matthijs de Buck
- Rob M. A. de Bie (ORCID: https://orcid.org/0000-0001-5267-0784)
- Matthan W.A. Caan (ORCID: https://orcid.org/0000-0002-5162-8880)
- Liza Afzali‐Hashemi (ORCID: https://orcid.org/0000-0001-9793-3357)
- Yarit Wiggerts (ORCID: https://orcid.org/0000-0001-8641-3639)
- P. Richard Schuurman
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/4194
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00